Derbyshire have lost their game at home to Northamptonshire at Chesterfield's Queen's Park.
Luke Proctor finished with four wickets as Northamptonshire wrapped up a 72 run victory.
Derbyshire went into the third day needing 164 with five wickets intact but were bowled out for 246.
Tom Lace top scored with 41 and Fynn Hudson-Prentice followed his first innings half century with an unbeaten 26 but Derbyshire never threatened to reach their target of 319.
Proctor finished with 4 for 26 and Ravi Rampaul provided some late entertainment by driving Matt Coles into the sightscreen before he pulled Ben Sanderson to deep square leg to seal a 22 point win for the visitors.
Derbyshire are back at Queen's Park on Saturday in T20 action against Yorkshire.