He's agreed a move to the National League North side until the end of the upcoming season.
Chesterfield forward Lee Shaw will be playing in West Yorkshire instead of North Derbyshire next season.
The 25 year old has signed for Guiseley on loan until the end of the 2019/20 campaign.
Spireites manager John Sheridan's hopeful he'll get more game time in the National League North;
"I don't want people just sitting around here, and Shawy totally accepted it, he knows the situation.
"Lee will go to Guiseley, but he'll still train with us, that's not a problem with me, he's a great lad.
"I don't see any problems whatsoever with the deal, so good luck to him."
Shaw scored one league goal last season in the National League for Chesterfield.