All of the men remain in police custody.
Officers investigating an alleged incident where a man suffered stab wounds are appealing to the public for information.
On Saturday 26 October, at around 7.45pm, officers were called to a flat on Hanbury Close in Holme Hall, Chesterfield.
On arrival a man was found with a number of injuries and was taken to hospital where he remains.
A 21-year-old man and a 23-year-old man were arrested on suspicion of attempt murder and possession of a class B drug.
A 32-year-old man was arrested on suspicion of possession with intent to supply a Class B drug and a 24-year-old man was arrested on suspicion of attempt murder.