Three men from Chesterfield and one from Birmingham were arrested on suspicion of drugs offences following a number of reports of police activity in Chesterfield last night.
A Derbyshire Police spokesperson said: "we were initially tracking the car believing that it may be related to an offence in SYP (South Yorkshire).
"The four men were arrested in connection with this, but later de-arrested in relation to this.
"Following further enquiries they were arrested by us in relation to drug offences in Derbyshire. Three of the men are from Chesterfield and aged 27 and two aged 19. The fourth man is from Birmingham and aged 18."